Epigenetics Analysis

Key advantages

• Comprehensive mapping of DNA methylation, histone modifications, and open chromatin

• Supports multiple assays: WGBS, RRBS, ATAC-seq, ChIP-seq, MeDIP-seq

• Enables regulatory variant discovery and epigenetic biomarker identification

• Applicable to development, disease, environmental exposure, and aging studies

• Single-base resolution methylation detection for precise epigenomic profiling

• Compatible with human, animal, plant, and microbial genomes

• Integrates with transcriptomic and genomic data for multi-layered interpretation

• Ideal for cancer epigenetics, neurobiology, and immune regulation research

Technical specifications

• Platforms: Illumina NovaSeq, MGI DNBSEQ for short reads; PacBio/Oxford Nanopore for direct methylation

• Input: high-quality gDNA or nuclei from fresh, frozen, or FFPE samples

• Assay types:
  • WGBS (Whole Genome Bisulfite Sequencing)
  • RRBS (Reduced Representation Bisulfite Sequencing)
  • ATAC-seq (Assay for Transposase-Accessible Chromatin)
  • ChIP-seq (Chromatin Immunoprecipitation)
  • MeDIP-seq (Methylated DNA Immunoprecipitation)

• Coverage: tailored depth depending on assay (e.g., 30–60M reads for ATAC-seq)

• Outputs: FASTQ, alignment (BAM), peak/methylation calls (BED), differentially methylated regions (DMRs)

• Bioinformatics: QC, alignment, methylation calling, peak detection, differential analysis, functional annotation

• Optional: multi-omics integration, pathway enrichment, chromatin state modeling

• Compliant with clinical and research data security standards